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br d Abbvie North Chicago IL United States
2019-09-23
d Abbvie, North Chicago, IL, United States of America e Department of Obstetrics and Gynecology, Univ. of Washington, Seattle, WA, United States of America f Department of Health Sciences Research, Mayo Clinic, Rochester, MN, United States of America g Erasmus Medical Center Cancer Instit
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br Details of Cardiac Toxicities
2019-09-20
Details of Cardiac Toxicities A total of 255 (7.9%) patients developed some form of a cardiac toxicity, among which 153 (4.7%) patients developed some form of arrhythmia and 62 (1.9%) patients developed an ischemic event. The remaining 40 patients developed non-specified forms of cardiac advers
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br cultures Additionally Rv cultures
2019-09-16
cultures. Additionally, 22Rv1 cultures had statistically significant in-crease in PSA expression in 6 wt% CA compared to 2 wt% and 4 wt% CA scaffold cultures. There were no significant differences in AR expression observed for C4-2B and 22Rv1 scaffold cultures. The C4-2B AR ex-pression was downreg
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br ER mediates the anti apoptotic e ect of
2019-09-16
ERα36 mediates the anti-apoptotic effect of E2 by activating PLD at the membrane leading to activation of LPA signaling and PI3K, which in turn leads to attenuation of the caspase cascade that promotes apoptosis [57]. E2-ERα36 signaling has also been implicated in the activation of other rapid path
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Size cm br b REF br REF br
2019-09-16
Size, cm b2 REF REF Grade REF Stage I REF REF Bold text designates statistical significance. Table 3 Cox proportional hazard model for factors associated with survival among patients who underwent Recurrence Score (RS) testing. Patients aged 70 years and older H
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Aspects of the immune system can contribute to
2019-09-03
Aspects of the immune system can contribute to tumor growth and development. High levels of circulating IL-6 is associated with a poor prognosis in lung cancer patients [3]. IL-6 signaling is propagated through the STAT1/3 pathways [4]. Activation of the signal transducer and activator of transcript
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Previous studies have identified several important factors r
2019-08-26
Previous studies have identified several important factors related to CRC mortality. Socioeconomic disparities and area-level socioeconomic disadvantage have been found to associate with CRC mortality [[5], [6], [7], [8]]. Better access to primary care and living in urban areas have also been shown
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A higher expression level of miR in Tongue
2019-08-16
A higher expression level of miR-21 in Tongue Squamous Cell Carcinoma (TSCC) is correlated with advanced clinical stage, poor differentiation and lymph node metastasis suggesting its potential to be used as a prognostic marker for TSCC patient survival [61]. MiR-31, miR-17, miR-125b, miR-155, miR-18
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br Results During and a total of individuals were
2019-08-16
Results During 2014 and 2015 a total of 886,088 individuals were invited to participate in the colorectal cancer screening. 571,918 individuals submitted a sample for analysis. From these 13,814 (2.4%) were excluded due to missing information, previous colorectal cancer diagnosis, deceased prior
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Ac-DEVD-CHO The principal causes of refusal in the present
2019-08-16
The principal causes of refusal in the present study were financial constraints and belief in the incurability of cancer. Our center caters mainly to poor patients, as 70% of our children (392/572) were of lower socioeconomic status (Table 2); this may be a plausible explanation for financial constr
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There is evidence of associations between exposure
2019-08-16
There is evidence of associations between exposure to traffic-related air pollution and various health outcomes, as outlined in a review study conducted by the Health Effects Institute [6], which identified the zones of exposure to such pollution as areas located 300–500 m from a major road. A numbe
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br Material and methods br Results
2019-08-11
Material and methods Results Discussion Conclusion Authorship contribution statement Disclosure of potential conflicts of interest Financial support This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. The w
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br Discussion To date no
2019-08-11
Discussion To date, no other population-based studies have examined the role of domperidone and liver cancer risk. Two laboratory studies conducted among mice, however, reported that stimulation of prolactin production decreased risk of liver cancer among males [31]. One of the two studies admini
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Significant clusters in female population
2019-08-11
Significant clusters in female population are rarer than those found among men. We found significant increased female clusters for MM and MPM, in correspondence to shipyards (Monfalcone, Livorno, Napoli), asbestos-cement plants (Casale Monferrato, Broni, Bari, and some towns of Reggio Emilia and Mod
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b iframe width height src https www
2019-08-11
r> Conflicts of interest Acknowledgements Introduction Lung cancer is the leading cause of cancer-related deaths among both men and women in the U.S. [1]. A recent study estimated that 8 million Americans are at high risk for lung cancer due to chronic high frequency smoking [2]. The Nationa