• br Materials and methods br Results br Discussion AKI

  2019-07-11

  

  Materials and methods Results Discussion AKI is a frequent complication in ICU patients, and approximately 50% of AKI cases are attributable to sepsis [21]. Sepsis and AKI synergistically increase morbidity and mortality in ICU patients. Therefore, a more complete molecular understanding of

• Quizartinib (AC220) Besides an infection of animals

  2019-07-08

  

  Besides an infection of animals with liver-tropic pathogens, an acute and/or chronic inflammatory milieu in the liver has also been generated by direct in situ expression of inflammatory factors, such as cytokines. Djilali-Saiah et al. used TTR-LCMV mice, which express the nucleoprotein (NP) of LCMV

• The recommendation of the European

  2019-07-08

  

  The recommendation of the European Association for the Study of the Liver (EASL) for the standard therapy of AIH is a glucocorticoid treatment with prednisone or prednisolone alone or in combination with azathioprine [37]. Alternative treatments include the next generation glucocorticoid budesonide

• Regardless of whether lack of basal thermogenic activity in

  2019-07-08

  

  Regardless of whether lack of basal thermogenic activity in brown adipocytes is sufficient to bring about a deleterious metabolic phenotype, many studies in rodents support the notion that enhanced activation of BAT and browning of WAT greatly influence Y-27632 balance and prevent obesity and obesit

• At this point it is at least clearly known that

  2019-07-06

  

  At this point, it is at least clearly known that O-GlcNAcylation plays a significant role in AD pathophysiology which makes this post-translational modification an attractive target to tackle this devastating neurodegenerative disease. Using a pharmacological approach to modulate O-GlcNAcylation in

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